Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases.
نویسندگان
چکیده
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.
منابع مشابه
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ورودعنوان ژورنال:
- Genetics
دوره 176 2 شماره
صفحات -
تاریخ انتشار 2007